NR1H4 and malignant colon neoplasm: Recently, Peng et al. [15] have demonstrated that treatment of colon cancer cell lines with FXR antagonist GS or FXR siRNA lead to phosphorylation of EGFR and ERK whereas treatment with GW4064 or FXR overexpression prevented cell proliferation by dephosphorylation of EGFR and ERK.