Moreover, the correlation between the frequency of TIGIT-expressing CD3+CD4+ T lymphocytes and anti-ENAs including anti-SSA, anti-SSB, anti-Ro52, anti-Sm, anti-nRNP/Sm, anti-rRNP, and anti-nucleosome were also investigated in SLE patients. Here, TRIM21 is linked to systemic lupus erythematosus.