In order to investigate the correlations between the frequency of TIGIT-expressing CD3+CD4+ T lymphocytes and inflammatory markers, inflammation markers including serum IgG, C3, C4 and ESR were determined and analyzed for their correlations with the frequency of TIGIT-expressing CD3+CD4+ T lymphocytes in patients with SLE. This evidence concerns the gene CD4 and systemic lupus erythematosus.