REL and Parkinson disease: Recently, we found iron and DMT1 accumulation in the substantia nigra (SN) of a mice model of neurodegeneration with Parkinsonism, the NF-kB/c-rel knockout mice (Baiguera et al., 2012), according to previous findings in Parkinson’s patients (Salazar et al., 2008), and during the early phase of brain ischemia (Ingrassia et al., 2012).