WDR45 and neurodegeneration with brain iron accumulation 5: De novo mutations in WDR45 gene on chromosome Xp11 have been found in patients with BPAN (Hayflick et al., 2013), a movement disorder with iron accumulation in the basal ganglia characterized by early childhood psychomotor retardation remaining static until the third decade of life, after which time affected individuals develop progressive dystonia-Parkinsonism and dementia (Haack et al., 2012, 2013; Lunt et al., 2013; Saitsu et al., 2013; Schneider et al., 2013).