In BPAN patients, where the impairment of autophagy is the principal peculiarity, due to mutations of WDR45 gene, involved in autophagosome maturation (Arber et al., 2016 and references therein), besides iron accumulation, we highlight a possible relationship between the impairment of iron homeostasis and the altered pattern of DMT1 and TfR with a consequent ferrous iron overload. The gene discussed is TFRC; the disease is neurodegeneration with brain iron accumulation 5.