TFRC and neurodegeneration with brain iron accumulation 5: We conversely found the concomitant down-regulation of TfR in the fibroblasts of BPAN patients (∗∗∗p < 0,001 and ##p < 0,01 respect to Controls; Figures 1A,B), in accordance with the canonical IRE/IRP post-transcriptional regulation during intracellular iron overload.