Recently, we found iron and DMT1 accumulation in the substantia nigra (SN) of a mice model of neurodegeneration with Parkinsonism, the NF-kB/c-rel knockout mice (Baiguera et al., 2012), according to previous findings in Parkinson’s patients (Salazar et al., 2008), and during the early phase of brain ischemia (Ingrassia et al., 2012). The gene discussed is REL; the disease is Parkinsonism.