For instance, hepatocellular carcinoma patients harbor significantly more peripheral Bregs compared to healthy controls (93); malignancy in non-small cell lung cancer is associated with an increased frequency of IL-10-producing Bregs, CD4+CD25+/highCD127low/− Tregs, and MDSCs (94); patients with tongue squamous cell carcinoma, gastric cancer, and colorectal cancer also exhibit a higher frequency of Bregs within the tumor itself compared to unaffected neighboring tissues, with numbers positively correlated with an increased frequency of Tregs (91, 95, 96). Here, CD4 is linked to neoplasm.