SMO and rheumatoid arthritis: The results of migration assay showed that suppression of Smo decreased the migration of RA-FLSs, with the numbers of migrated cells 40.33 × 104 ± 3.28 × 104, compared to that of the NC-siRNA group (99.00 × 104 ± 6.81 × 104, Figure 4E, P < 0.05).