ADAM8 and systemic sclerosis: In addition, because sclGvHD demonstrates a gene expression pattern similar to the inflammatory subset of scleroderma (13, 14) and increased expression of extracellular matrix-associated pathways is evident in this inflammatory subset (13), we also examined the expressions of TGF-β, TIMP1, MMP-12, ADAM8, IL4RA, and CCL2 genes which have been previously shown to be upregulated in both murine sclGvHD and the inflammatory subset of SSc patients (13, 14, 21, 22).