In basal-like breast cancer, stimulated transcription of miR-221/222 by basal-like transcription factor FOSL1 (Fos-like 1, also named Fra1) can promote epithelial-to-mesenchymal transition (EMT) via targeting the 3′UTR of trichorhinophalangeal 1 (TRPS1), leading to increased cell migration and invasion (15). Here, FOSL1 is linked to breast cancer.