Wang et al. found that miR-221/222 promoted cell proliferation and repressed apoptosis of prostate cancer cells by repressing caspase-10, and prostate cancer cells were sensitized to tumor necrosis factor-a/cycloheximide (TNF-α/CHX)-induced apoptosis after miR-221/222 knockdown (84). The gene discussed is TNF; the disease is Familial prostate cancer.