The combined treatment of severe combined immunodeficient/non-obese diabetic mice bearing human melphalan-refractory MM xenografts with LNA-i-miR-221 and melphalan can also overcome drug resistance and induce antitumor activity, which is associated with upregulation of BBC3/PUMA and downregulation of ABCC1 (52). This evidence concerns the gene ABCC1 and Miyoshi myopathy.