CDKN1B and breast cancer: Li et al. also reported that a significantly higher expression of miR-221/222 was observed in highly invasive basal-like breast cancer, which could contribute to S-phase entry, cellular migration, and invasion through the downregulation of suppressor of cytokine signaling 1 (SOCS1) and cyclin-dependent kinase inhibitor 1B (CDKN1B) (17).