The 13-mer locked nucleic acid-inhibitor-miR-221 (LNA-i-miR-221) had remarkable anti-proliferative effect on t(4;14)-translocated MM cells via strong derepression of p27, and significant antitumor activity against t(4;14) MM xenografts was also observed after 2 weeks of exposure to LNA-i-miR-221 with upregulated p27 and reduced Ki-67 (51). This evidence concerns the gene CDKN1B and Miyoshi myopathy.