Yang et al. observed an increase in SIRT1, cell proliferation, and apoptosis and decrease in migration reduction after transfecting PC-3 cells with miR-221/222 inhibitor, thereby suggesting that the tumor-promoting role of miR-221/222 might be mediated by the activation of silent information regulator two homolog one (SIRT1) (30). Here, SIRT1 is linked to neoplasm.