Treatment of HSV-tk (herpes simplex virus thymidine kinase)-transduced MC38 (murine colon cancer) cells with sulfasalazine (a NFκB inhibitor) lead to the inhibition of NF-κB activity, inhibitor-κB phosphorylation and nuclear translocation of NF-κB (Konson et al., 2006). Here, NFKB1 is linked to colonic neoplasm.