Inhibition of the eCB hydrolytic enzymes FAAH (Tchantchou et al., 2014), MAGL (Zhang et al., 2014), and ABHD6 (Tchantchou and Zhang, 2013) have been shown to protect against TBI-induced memory impairments, suggesting that anandamide and 2-AG elevation post-TBI may offer protection from TBI-induced learning and memory deficits. The gene discussed is MGLL; the disease is memory impairment.