CXCL8 and Keratoconjunctivitis sicca: In a hyperosmotic environment, pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), and IL-1β are detected in corneal cell lines or dry eye patients (Solomon et al., 2001; Li, 2006; Chotikavanich et al., 2009).