Curcumin could reverse the decrease of mfn2 and the increase of Nrf2 in the retinal I/R-induced glaucoma model. It protected retinal neurons and microvessels against I/R injury, may occur through its inhibitory effects on injury-induced activation of NF-κB and STAT3, and over-expression of MCP-1. Here, STAT3 is linked to glaucoma.