Pretreat of curcumin may reverse the decrease of mfn2 and the increase of nuclear factor erythroid 2-related factor 2 (Nrf2) in the retinal I/R-induced open-angle glaucoma model in vivo, indicating that curcumin could maintain the normal mitochondrial function and alleviate the retinal I/R injury by regulating the antioxidant system (Wang et al., 2011). The gene discussed is NFE2L2; the disease is open-angle glaucoma.