Consistent with our data, curcumin was shown to inhibit the activation of NF-κB (Kao et al., 2016; Ruiz de Porras et al., 2016), Bharat et al. has reported curcumin down-regulates the constitutive activation of NF-κB and IκBα kinase in human multiple myeloma cells (Bharti et al., 2003). This evidence concerns the gene NFKB1 and plasma cell myeloma.