MAPT and Alzheimer disease: Inestrosa et al. (2012) reported a correlation between loss of Wnt signaling and Aβ toxicity as well as tau hyperphosphorylation, and that conversely, upregulation of the Wnt pathway prevented toxicity. In addition, Liu et al. indicated dysfunctional Wnt/β-catenin signaling affects BBB function and contributes to neurodegeneration in AD (Liu et al., 2014).