Statins are also known to have anti-proliferative effects in certain tumor cell types (Baulch-Brown et al., 2007; Relja et al., 2010) and this effect is attributed in part to reduction of the isoprenylation of proteins involved in cell signal transduction such as Ras and RhoA (Cafforio et al., 2005). The gene discussed is RHOA; the disease is neoplasm.