Due to the highly specific Septin5 expression in the brain and, in particular, its localization at nerve terminals (Kinoshita et al., 2000; Xue et al., 2004; Yang et al., 2010; Tsang et al., 2011) the involvement of Sept5 in exocytosis (Beites et al., 1999, 2005), as well as the interaction of Sept5 with PARK2 (Zhang et al., 2000) has linked this particular Septin to diseases of the nervous system like, schizophrenia, epilepsy and degenerative diseases like Parkinson’s and Alzheimer’s (Dolat et al., 2014; Marttinen et al., 2015). Here, PRKN is linked to neurodegenerative disease.