GRIN2B and autism: Importantly, all molecules changed in the striatal Shank3Δ11-/- mutant PSD that matched with the SFARI autism gene database were reduced and comprised the murine homologs of proteins encoded by several major ASD candidates (Figure 3A) including NCKAP1, GRIN2B and TRIO, 3 of the 65 high-risk ASD TADA genes (De Rubeis et al., 2014; Sanders et al., 2015).