Among these is Cdkl5, a serine/threonine kinase involved in Akt-mTOR signaling at the synapse, genetically related to several neurodevelopmental disorders in humans including ASD, Rett syndrome and epileptic encephalopathies and whose disruption leads to ASD-like behavior and impaired neural circuitry in mice (Wang et al., 2012; Sivilia et al., 2016). This evidence concerns the gene MARK2 and atypical Rett syndrome.