CASR and Alzheimer disease: In the DG an increase in CaSR expression was most prominent in the molecular layer (ML) of 3xTg-AD animals respect to their controls (15.90% at 9 months, 12.32% at 12 months, 20.98% at 18 months; Figure 3B) and in the granular cell layer (GCL, 19.33% at 9 months, 10.68% at 12 months, 37.38% at 18 months; Figures 1I,J, 3C; Table 1).