CASR and Alzheimer disease: Optical density analysis of CaSR staining in the hippocampus of the 3xTg-AD mouse showed a significant increase in its expression in CA1 and DG subfields [F(7, 166) = 11.32, p < 0.0001 and F(7, 166) = 7.994, p < 0.0001, respectively] at all ages (9, 12, and 18 months; Figures 1, 2).