In CA1 we found that the increase in CaSR expression in 3xTg-AD animals mainly occurred in the pyramidal cell layer (PCL, 10.68% at 9 months, 2.28% at 12 months, 20.17% at 18 months; Figure 2B), in the stratum radiatum (SR, 12.93% at 9 months, 27.71% at 12 months, 14.55% at 18 months; Figure 2C) and in the stratum lacunosum moleculare (SLM, 93.19% at 9 months, 39.58% at 12 months, 56.08% at 18 months; Figures 1G,H, 2D; Table 1). Here, CASR is linked to Alzheimer disease.