For instance, ADAM17 enhances migration and invasion of breast cancer and glioblastoma stem cells by promoting EGFR signaling through shedding of several EGFR ligands [214, 215, 242] and PI3K/AKT activation, for example, shown for TGF-α shedding in triple-negative breast cancer cell invasion [215] and EGFR activation in hypoxia-induced glioma cell invasion [243]. Here, EGFR is linked to central nervous system cancer.