Knockdown of MYB expression using lentivirus-transduced shRNA decreased the expression of LMO1 significantly in Jurkat cells (Figure 3d), indicating that MYB binding to the somatically acquired heterozygous MYB binding motif leads to enhanced expression of LMO1 in T-ALL from the same allele. The gene discussed is LMO1; the disease is acute lymphoblastic leukemia.