CD34 and acute lymphoblastic leukemia: The previously identified normal hematopoietic cell enhancer downstream of the LMO1 gene is evident in normal CD34+ HSPCs20 and in the Loucy cell line (Figure 1b), which has an early T-cell precursor (ETP ALL) phenotype.25 The aberrant active enhancer we identified was present upstream of the LMO1 gene in RPMI-8402 and Jurkat T-ALL cell lines, but not in normal CD34+ HSPCs or normal thymus (Figure 1b).