As we and others have shown for TAL1,12, 35 knockdown of LMO1 transcripts by lentivirus-transduced shRNA in Jurkat cells demonstrates that high levels of LMO1 expression are required for cell survival (Figures 4c and d), emphasizing that aberrant enhancer elements can alter gene expression sufficiently to qualify as oncogenic drivers in T-ALL, despite their lack of full super-enhancer status. This evidence concerns the gene TAL1 and acute lymphoblastic leukemia.