One cause of aberrant expression of LMO1 is the t(11;14)(p15;q11) LMO1-TCRD rearrangement.9, 15, 16, 17 However, <1% of T-ALL patients harbour activating translocations involving LMO1, which cannot explain its overexpression in each T-ALL case that aberrantly overexpresses the LMO1 mRNA,18, 19, 20 suggesting that other types of genetic abnormalities can cause aberrant expression of the LMO1 gene. The gene discussed is LMO1; the disease is acute lymphoblastic leukemia.