In a recent study, Ertych et al. demonstrated that increased assembly rates by Aurora A-overexpressing or loss of Chk2 in colon cancer cells resulted in abnormal microtubule spindle geometry and a subsequent increase of chromosomal instability (CIN), which is one of the characteristics of tumor cells and a driving force for cancer development [37, 38]. The gene discussed is CHEK2; the disease is malignant colon neoplasm.