Genes that are commonly hypermethylated in CRC include MLH1, MCC (methylated in CRC), APC and MGMT. The promoter region of five genes has been chosen as proxy markers of CIMP: CACNA1G, IGF2, NEUROG1, RUNX3 and SOCS1 [6]. This evidence concerns the gene RUNX3 and colorectal carcinoma.