reported a distinct cardiac phenotype in two NLSDM siblings carrying the same homozygous PNPLA2 mutation; according to the hypothesis that there is a gender difference on the phenotypic clinical expression in NLSDM, the male died at age of 31 of heart failure, while his sister was still alive (44 years), although presenting hypertrophic cardiomyopathy [20]. This evidence concerns the gene PNPLA2 and hypertrophic cardiomyopathy.