Also, metformin, a herbal compound widely prescribed as oral hypoglycaemic drug for the treatment of type 2 diabetes, acts by SIRT1 activation (and FOXO1 elevation) in endothelial dysfunction caused by diabetes-related microvascular disease associated with accelerated endothelium senescence and ageing (Arunachalam et al. 2014). The gene discussed is SIRT1; the disease is diabetes mellitus.