COL1A1 and neoplasm: Interestingly, COL1A1, PRPF40A, and UCP2 expression was linked to the metabolic pathways implicated in hypoxia and oxidative stress (Baffy 2010; Falanga et al. 2002; García-Trevijano et al. 1999; Papaiahgari et al. 2007), events associated with more aggressive and therapy-resistant tumours (Harris 2002; Landriscina et al. 2009).