Although UCP2, PRPF40A, and COL1A1 upregulation has been previously observed in malignant tissues (Ayyasamy et al. 2011; Ramaswamy et al. 2003; Thakur et al. 2008) and associated with response to hypoxia and oxidative stress (Baffy 2010; Falanga et al. 2002; García-Trevijano et al. 1999; Papaiahgari et al. 2007), little is known about their status in lung cancer. This evidence concerns the gene UCP2 and lung cancer.