CYGB and neoplasm: Our previous studies suggested cytoglobin (CYGB) as a putative tumour suppressor gene in lung (Xinarianos et al. 2006) and oesophageal (McRonald et al. 2006) tumours and successive in vitro and in vivo studies provided further evidence in support of this hypothesis (Oleksiewicz et al. 2013; Shivapurkar et al. 2008; Thuy le et al. 2011).