Although important discoveries were made by these experiments, it should be noted that the important role of OSMR-β in atherosclerosis indicated by our study mainly revealed its effect in macrophages because we observed that OSMR-β was predominantly located in macrophages in atherosclerotic plaques and the BMT experiment further demonstrated that OSMR-β deficiency from macrophage was responsible for inhibition of atherogenesis. This evidence concerns the gene OSMR and atherosclerosis.