Subsequently, to explore the OSMR-β expression pattern in atherosclerotic lesions harvested from the mouse model, we grouped atherosclerosis-prone ApoE−/− mice by feeding them either NC or a HFD for 28 weeks, and the result indicated that HFD feeding significantly induced OSMR-β expression in the mouse aortas (Fig. 1B). The gene discussed is APOE; the disease is atherosclerosis.