In our work recently reported in the paper entitled “Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer” in Nature Communications [9], ailanthone not only blocked the ligand-induced activities of full-length AR but also inhibited AR-V which lacks the LBD at low concentrations (AR-FL half maximal inhibitory concentration [IC50] = 69 nmol/L, 95% confidence interval [CI] = 53–89 nmol/L; AR1–651 [a constructed AR splice variant] IC50 = 309 nmol/L, 95% CI = 236–687 nmol/L in 22RV1 cells). Here, AR is linked to Familial prostate cancer.