Meanwhile, the two caspase inhibitors significantly attenuated the WYE-687-induced reduction in 786-O cell viability (Fig 2D).Annexin V assay results in Fig 2E showed that WYE-687 (100 nM, 36 hours) similarly induced profound apoptosis in A498 RCC cells and primary human RCC cells. The gene discussed is ANXA5; the disease is renal cell carcinoma.