ANGPTL8 and diabetes mellitus: In our own cohort consisting of 535 patients from the MesyBePo follow-up study with a normal to mildly impaired renal function (average eGFR of 81.2 ml/min at an average of 55.6 years; 6% of participants diagnosed with diabetes) betatrophin showed a similarly strong independent correlation of circulating hormone levels and renal function.