We found participants with diabetes having significantly higher betatrophin levels than individuals having a normal glucose metabolism, with no significant differences for people with an impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both (IFG+IGT) compared to controls (One-way ANOVA p < 0.001; mean betatrophin concentration: controls = 506.4 pg/ml, IFG = 601.1 pg/ml (p = 0.42), IGT = 554.6 pg/ml (p = 1.0), IFG+IGT = 643.2 pg/ml (p = 0.873), type 2 diabetes 659.9 pg/ml (p < 0.001)). The gene discussed is ANGPTL8; the disease is Impaired glucose tolerance.