SLC9A3 and hypertensive disorder: Depressing apical Na+ entry without hypertension is not sufficient to decrease Na/K-ATPase activity, and depressing Na/K-ATPase activity alone is not sufficient to decrease RPT Na+ reabsorption; thus, it was proposed that coordinated decreases in both NHE3 surface distribution and Na/K-ATPase activity may be important for the response to hypertension [65,101,102,103].