As described above, dendrimer-entrapped gold nanoparticles (Au DENPs) were successfully used as platform for the delivery of vascular endothelial growth factor (VEGF) or B-cell lymphoma/leukemia 2 protein (BCL-2) siRNA into a human glioma cell line [22] or BCL-2 siRNA to a human cervical carcinoma cell line, for silencing of luciferase (LUC) reporter gene and enhanced green fluorescent protein (EGFP) gene [23]. Here, VEGFA is linked to central nervous system cancer.