Most Bcr-Abl resides in the cytoplasm [30,31] and causes the malignant proliferation of CML cells by activating multiple signaling pathways, including JAK/STAT, MAPK/RAS/ERK and PI3K/Akt pathways [32,33]. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.