In this case, vanillin dramatically down-regulates HIF-1α promoter activity (Figure 5A) and its target genes involved in glycolytic metabolism (CA-IX, PDK1, GLUT1, and LDHA: carbonic anhydrase 9, pyruvate dehydrogenase kinase 1, glucose transporter 1, and lactate dehydrogenase A) and cancer metastasis (FN1, LOXL2, and uPAR) under hypoxia in A2058 and A375 cells (Figure 5B,C). Here, SLC2A1 is linked to cancer.