TP53 and lung cancer: However, when loss of p53 (by inactivation or mutation), one of the most common events in cancer, occurs, inactivated or mutated p53 is unable to reduce the recruitment of NF-Y to the PRR11-SKA2 promoter region, eventually leading to the significant upregulation of PRR11-SKA2 and tumor progression in lung cancer with worse prognosis (Figure 5B).