Interestingly, Lf as a single component failed to eradicate the H.pylori infection but in combination with triple esomeprazole, clarithromycin and amoxicillin therapy and with probiotics, favored the resolution of infection and ameliorated the inflammatory response more effectively than in combination with two-antibiotic treatment, as described in experimental mice treated with r-hLf from transgenic goats, and also in trails of patients treated with native bLf. The gene discussed is LTF; the disease is infection.