Murine model of infection of urinary bladder with the uropathogenic E. coli O6K5 strain showed that perorally administered hLf decreased the bacterial load in the kidneys and urinary bladder as well as the inflammatory response, as evidenced by reduced IL-6 levels in urine at 2 h post-infection, and in plasma, at 24 h post-infection [126]. The gene discussed is HLF; the disease is infection.