Reduction of proliferation and increase of anchorage-independent growth is consistent with the promotion of stem-like phenotype, and we suggest that the role of KLF4 in glioblastoma mirrors that in Multiple Myeloma, where increased KLF4 levels are associated with an overall reduction of proliferation, but greater resistance to alkylating chemotherapy agents21. This evidence concerns the gene KLF4 and plasma cell myeloma.