Future work may define how KLF4 is involved in other aspects of GBM biology such as its cerebral invasive nature, as suggested by a previous study that showed EGR1 transcriptionally regulates KLF4 to induce in-vitro cell-scattering, in part, by suppressing the expression of E-Cadherin in 2 different established cell-lines29. This evidence concerns the gene CDH1 and glioblastoma.