Carro et al. 18 also used global gene expression data from clinical glioma samples to infer the activity of master regulators STAT3 and CEBPB in the Mesenchymal subtype of glioblastoma and showed that these transcription factors could reprogram a glioma cell line towards a mesenchymal lineage18. The gene discussed is CEBPB; the disease is central nervous system cancer.