While PIK3CA mutations have now been reported to be present in 25–30% of human cancers including colorectal, gastric, oral squamous and brain70, 71, 72, this frequency is at a lower rate for NPC (5–9%)29, 73, 74, despite reported being amplified and overexpressed in ~70% of lesions analyzed75. The gene discussed is PIK3CA; the disease is nasopharyngeal carcinoma.