In the Nf1fl/fl;DhhCre plexiform neurofibroma model, pharmacological inhibition of macrophage/mast cell function with a dual Kit/Fms (c-kit/Csf1r) kinase inhibitor reduced macrophage accumulation and growth of established neurofibromas (age 7–9 months)14. This evidence concerns the gene KIT and plexiform neurofibroma.