A strong correlation between the levels of TNFR1 and TNFR2 was observed even in patients undergoing haemodialysis, as well as in predialysis CKD patients or patients in a community-based setting; however, the levels in haemodialysis patients were much higher than those in patients with residual renal function12, 17, 18, 19. The gene discussed is TNFRSF1B; the disease is chronic kidney disease.