The oncogenic function of REST was identified in medulloblastoma16, 17 and glioblastoma18, while the tumor suppressor role of REST was elucidated in colorectal cancer19, 20, breast cancer21, 22, PCa9, 10, 11, 12, 13 and small cell lung cancer (SCLC)23, 24. The gene discussed is REST; the disease is small cell lung carcinoma.