This study was also collected the data of GC patients’ clinicopathologic characteristics and examined the relationship between Trop2 and AREG protein expression and clinicopathologic parameter in GC patients (Table 2).The result indicated that T+A+ expression in GC was significantly associated with TNM stage (χ2 = 50.345, P < 0.001), tumor size(χ2 = 40.349, P < 0.001), lymph node metastases (χ2 = 26.481, P < 0.001), and distant metastases(χ2 = 8.387, P = 0.039). This evidence concerns the gene AREG and gastric cancer.