2013). This proposed system may be indicative of a complex mechanism in controlling the physiological functions of endogenous apelin that may be important in a hypertensive disease state, in which apelin secretion increases BP by inducing VP release. Further studies are needed to determine whether there are other vasoactive peptides with which apelin and APJ may interact, as well as the specific mechanisms involved in the regulation of [Pyr1]apelin‐13‐mediated cardiovascular control within the RVLM. This evidence concerns the gene APLNR and hypertensive disorder.