The results suggest that HSPB1 is more important in the present system at conferring resistance to these drugs, and are supported by findings from Sharma et al. (2009) who show increased sensitivity to 5-FU following siRNA silencing of HSPB1, and also DNAJB1 (Hsp40) in hepatoma cells. This evidence concerns the gene HSPB1 and hepatocellular carcinoma.