HSPA1A and HSPB1 have both been implicated in chemoresistance towards 5-FU in CRC (Grivicich et al. 2007; Tsuruta et al. 2008; Ang et al. 2010), whilst Choi et al. (2007) observed that in IRN-resistant CRC cell lines, significantly higher protein levels of HSPB1 were expressed. The gene discussed is HSPB1; the disease is colorectal carcinoma.