TP53 and neoplasm: A variety of histological biomarkers for NFPA have been investigated for their relationship to invasiveness and tumor recurrence, including the proliferation marker Ki-67, cellcycle-related factors such as p27 and galectin-3, and other molecules such as p53,O-6-methylguanine-DNA methyltransferase, and matrix metalloproteinase 9 [5–7].