HMGA1 and cancer: The HMGA protein family includes HMGA1 and the closely related HMGA2 protein, which are non-histone chromosomal proteins that target the minor groove of AT-rich DNA strands through their adenine/thymine-binding motifs [27].HMGA overexpression is a feature of cancers of the colon, rectum, breast, pancreas, ovary, lung, esophagus, and testis, among others, and can be used to predict patient prognosis and drug response [28].