Hepatoma cell lines and PHH have also been used to study how the IFNL subtypes differ in their ability to limit viral infections; IFNL3 and IFNL4 induce the same set of ISGs in PHH [105] and the two subtypes have the same antiviral activity against HCV in an overexpression setup in hepatoma cells. The gene discussed is IFNL3; the disease is hepatocellular carcinoma.