Though no direct relationship between PTK7 and epilepsy has been confirmed, recent publications reported that PTK7 may participate in the metabolism of antiepileptic drugs (AED), suggesting that there may remain uncovered interactions between PTK7 and epilepsy, validating our prediction [87]. GSK3A, as a multifunctional Ser/Thr protein kinase, has been reported to contribute to glycogen synthesis and transcriptional regulation [88, 89]. Here, GSK3A is linked to epilepsy.