Translocations leading to the fusion of a strong activating domain of transcription (of another TF) with the ligation domain of an ETS (e.g. EWS fused with FLI1 or ERG in Ewing sarcome - Delattre 1992; Sorensen 1994) and/ or an overexpression of a member of the ETS family, due to the insertion of a strong cis-activating element upstream of its gene (Tomlins 2005, 2007), are more common in cancers. Here, ERG is linked to cancer.