Chromosome 14q32.12 was strongly associated to PDB (p value = 2.55e-11, OR = 1.44 [1.29–1.60]) in the European population, appointing to Ras and Rab interactor 3 (RIN3) as the causal gene, since small GTPases, like Ras and Rab, are important for osteoclast function [94, 95], and molecules involved in vesicular trafficking cause syndromes with PDB-like characteristics, namely inclusion body myopathy with early onset Paget’s disease and frontotemporal dementia [96]. Here, RIN3 is linked to Paget disease.