HNF4A and non-small cell lung carcinoma: In addition, HNF4A (a negative downstream gene of NKX2‐1; Maeda et al, 2012) that is expressed in human IMA was negatively correlated with NKX2‐1 and PD‐L1 in the 105 NSCLC cell lines (Fig 3E) and the 230 TCGA LUAD cases (Fig 3G), further suggesting a negative association of PD‐L1 with human IMA.