CD44 is one such molecule that has been associated with CSCs in several types of tumors, promotes ROS resistance by interacting with and stabilizing the cystine/glutamate transporter xCT in human gastrointestinal cancer, and increased CD13 expression reduces ROS levels, promoting the survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon [22, 23]. This evidence concerns the gene SLC7A11 and liver cancer.