EZH2 and breast carcinoma: When using this scale, normal breast epithelium with more than 20% expression of EZH2 expression was associated with a 2.44-fold increased risk of breast cancer (OR = 2.44, 95% CI = 1.15–5.17), which was even higher when also adjusting for the BBD lesion present and for proliferative activity (OR = 2.95, 95% CI = 1.11–7.84) (Table 2).