These included CRP, historically the most commonly examined acute phase protein biomarker in humans; pentraxin 3 (PTX3), a systemic acute phase protein expressed in vivo more rapidly than CRP and prominent in chronic inflammation; soluble IL-1R Accessory protein (IL-1RAcP), a widely expressed protein integral to pro-inflammatory signaling and linked to asthma, autoimmunity and other inflammatory conditions; and sST2, an increasingly used predictive biomarker of inflammatory disorders and increased risk of mortality in cardiovascular disease. This evidence concerns the gene PTX3 and cardiovascular disorder.