A total of 60 cases with pleural invasion were found, including 43 and 17 patients with mutated and wild-type EGFR, respectively; there were 32 cases of lymph node metastasis, including 22 and 10 patients with mutated and wild-type EGFR, respectively. The gene discussed is EGFR; the disease is metastatic malignant neoplasm in the lymph nodes.